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Excessive sedation may occur when promethazine is combined with other medications that depress the central

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nervous system (brain) and cause sedation. Promethazine also causes anticholinergic side effects such as blurred vision, dry mouth, dilated pupils, nausea, urinary retention (inability to urinate), impotence, and constipation. Such drugs include antipsychotics, metoclopramide (Reglan), and amoxapine (Asendin). Promethazine is prescribed for treating nausea or vomiting,
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motion sickness, and allergic reactions and for
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sedation. Concurrent use of promethazine with the dye used for myelography (x-rays of the spinal juan) can lower the threshold for seizures and thus increase the risk of seizures. Promethazine should be stopped at least 48 hours
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before myelography and not restarted until at least 24 hours after myelography. Pattie 23 more promethazine related articles ... Promethazine should not be used with propylthiouracil
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(PTU) due to the increased risk of low white blood cell counts and increased risk of infections.

The FDA approved promethazine in 1951. The reason for this interaction is not known. Promethazine should not be taken with any of the MAO (mono-amine oxidase) inhibitor-class

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of antidepressants, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane), because of the increased risk of extrapyramidal symptoms (EPS)--uncontrollable movement disorders. Promethazine also blocks the action of acetylcholine (anticholinergic effect), and this may explain its benefit in reducing the nausea of motion sickness. Tablets, syrup and injection should be stored at room temperature between
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15-25 C (68-77 F). Printer-Friendly Format Email to a Friend From the Doctors at Allergy - Get the facts about
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allergic reactions, causes, allergy types (food, dust, mold, seasonal), symptoms and signs (skin rash, itching, red bumps, sneezing).

Allergic reactions are treated with 6.25-25 mg 3 times daily. Suppositories are unwrapped and moistened with water before insertion into the rectum. Suppositories

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should be stored at 2-8 C (36-46 F).

In children less than two it can depress respiration and lead to death. Phenergan, Phenadoz, Promethegan. Tablets may be taken with or without food. Doses of 12.5-50 mg at bedtime are used for sedation.

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There may be an increase in the risk of certain neurologic reactions that affect movement of muscles (EPS, see below) when promethazine is combined with medicines that also cause EPS. There are no adequate studies of promethazine in pregnant women. Antihistamines such as promethazine compete with histamine for one of the receptors for histamine (the H1 receptor) on cells. Administration
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delivery may affect platelet function in the newborn.

If the suppository is too soft from being stored in a warm place, it may be chilled in the refrigerator for 20 to 30 minutes or placed in cold water before the wrapper is removed. However, unlike the other drugs in this class, promethazine is not used as an anti-psychotic.

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Therefore, it should not
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be used in children less than two years old. 12.5, 25, and 50 mg; Suppositories.

Such drugs include ethanol, barbiturates, anti-anxiety medications, sedatives, other phenothiazines, and narcotic pain medications. It is used as a sedative because it causes drowsiness as a side effect. What's Behind Cloverfield' Illness?. Ironically,

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sometimes stimulates patients, particularly children. Nausea and vomiting may be managed with 12.5-25 mg administered every 4-6 hours as needed. However, when the antihistamines bind to the receptors they do not stimulate the cells. Instead, they prevent histamine from binding
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and stimulating the cells. 1 2 3 Next promethazine Index Glossary Report Problems to the Food and Drug Administration
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You are encouraged to report negative side effects of prescription drugs to the FDA.

It used as an anti-histamine, sedative,

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and antiemetic (anti-nausea). Oral, rectal and injectable doses are similar. Such stimulation may be manifest by restlessness, inability to sleep, heart palpitations or even seizures. Excessive anti-cholinergic effects (described below) can occur when promethazine is used with other antihistamines, for example, diphenhydramine (Benadryl); some phenothiazines, for example, thioridazine (Mellaril); some tricyclic antidepressants, for example, amitriptyline (Elavil); clozapine (Clozaril), cyclobenzaprine (Flexeril), and disopyramide (Norpace). A single 25 mg dose administered at bedtime also may suffice. Promethazine injections are used when the oral route is not possible (for example, with severe vomiting). For
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prevention of motion sickness, 25 mg is used 30 to 60 minutes before the motion begins and then every 8 to 12 hours as needed. When histamine binds to its receptors on cells, it stimulates changes within the cells that lead to sneezing, itching, and increased mucus production.

The body releases histamine during several types of allergic reactions. It is not known whether promethazine is excreted in breast-milk. Visit the FDA website or call 1-800-FDA-1088. Promethazine often causes sedation. Promethazine is a phenothiazine in the same drug class as chlorpromazine (Thorazine) and trifluoperazine (Stelazine).

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