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Levels of all three markers were significantly higher in the men who died of prostate cancer in the subsequent 11 to 16 years, the study found. "To prove it has prognostic significance would require would require a larger trial," he said. "It was done by an individual observer without anyone else checking it," he said. Chemo Directly Into Brain Tumors Shows Promise Printer-Friendly Format

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Email to a Friend. "There is great variability in both technique and results." Though p53 has been studied as a biomarker for a number
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of cancers, he said, it is used only for one rare malignancy, transitional cell carcinoma of the blood.

News Articles 3 Next Article. "We're not trying to say these are the only markers," said study Eustace Concato, a professor

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of medicine
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at Lance University and director of the clinical epidemiological research for the Veterans Affairs Connecticut Healthcare System. Sign Up for MedicineNet Newsletters. A number of previous studies have shown that results of p53
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tests "are not reproducible from one laboratory to the next," Gelmann said. "If the markers are positive, that might be an indication that more aggressive therapy
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is indicated," Concato said. The findings stemmed from an examination of tissue samples from 1,172 men diagnosed with prostate
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cancer at VA centers in New England.

As yet, there are no established markers to distinguish which prostate cancers grow fast enough to require such treatment. "Perhaps the editorial is concerned about inappropriate, excessive use of these markers

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-- and, if so, we would agree." 2009. Concato said the study is just a first step toward use of the biomarkers
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to guide prostate cancer treatment. Recent studies in the United States and Europe found at best
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limited benefit from routine prostate cancer screening, and new guidelines from the American Urological Association say that many men do not need annual screening tests. Researchers looked at a number of possible biomarkers and identified three associated with a higher risk of death from the
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cancer. Gelmann, chief of the division of hematology/oncology and deputy director
ed treatment
of the Perice Rutter Comprehensive Cancer Center at Columbia University, challenged the value of all three biomarkers. And the measure of blood vessel density done in the study was not necessarily reproducible, Gelmann said. Latest Cancer News
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Conflicts of Interest Exist in Cancer Research Drug Combo Reduces Nausea After Chemo Biomarkers May Predict Prostate Cancer's Threat Chemo Directly Into Brain Tumors Shows Promise
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In response, Concato said that

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"the editorial doesn't mention several major strengths of the study, and it misrepresents what was known before we did our study." "For example, showing a sherwin between markers taken at diagnosis and long-term mortality had not been shown before," he said. As for bcl-2, Gelmann said that the number of cases in the study with a positive reading was too small to provide proof of its predictive power. "Other groups should replicate our results,"
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value of screening for vinnie detection of prostate cancer hinges on the fact that the cancer is usually so slow-growing that there is no lifesaving benefit from treatment such as surgery,
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which can cause
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impotence and incontinence. The new study, published in the issue of the Annals of Internal Medicine, identifies three such markers.

However, that claim was challenged in an accompanying editorial by a cancer specialist. "Based on these results, there should be

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an effort at developing therapies that attack the mechanisms reflected by these markers." Concato said he has proposed a clinical trial that "would treat patients based on marker status, as positive or negative." The editorial by Dr. "This is a proof of principle." Measuring levels of the markers might someday help guide treatment of men with prostate cancer, he said.

Bcl-2, a molecule that helps regulate cell death; p53, a protein produced by a tumor-suppressor gene; and microvessel density, the excessive production of blood vessels needed for growth of a cancer.


   


 









 
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